Affiliation:
1. Gastrohepatology Group, Faculty of Medicine, Universidad de Antioquia (UdeA), Calle 70 No. 52-21, Medellin 050010, Colombia
Abstract
Hepatitis B virus (HBV) infection is a major public health problem in the world. Approximately 296 million people are chronically infected. In endemic areas, vertical transmission is a common route of transmission. There are several strategies for the prevention of HBV vertical transmission, such as antiviral treatment during the third trimester of pregnancy and immunoprophylaxis to newborns that includes the administration of hepatitis B immune globulin (HBIG) and an HBV vaccine. Despite this, immunoprophylaxis failure can occur in up to 30% of infants born to HBeAg-positive mothers and/or with high viral load. Therefore, management and prevention of HBV vertical transmission is of paramount significance. In this article, we provided a review of the epidemiology, mechanisms of pathogenesis and risk factors of vertical transmission, as well as the strategies implemented to prevent the infection.
Funder
Vicerrectoria de Investigacion, Universidad de Antioquia
Subject
Virology,Microbiology (medical),Microbiology
Reference120 articles.
1. World Health Organization (WHO) (2022, December 02). Hepatitis B, Available online: https://www.who.int/news-room/fact-sheets/detail/hepatitis-b.
2. (2022, November 02). Global Health Sector Strategy on Viral Hepatitis 2016–2021. Towards Ending Viral Hepatitis. Available online: https://apps.who.int/iris/handle/10665/246177.
3. Hepatitis B Virus Infection;Illiam;N. Engl. J. Med.,1997
4. Hepatitis B: The Virus and Disease;Liang;Hepatology,2009
5. Geographical and Genetic Diversity of the Human Hepatitis B Virus;Kurbanov;Hepatol. Res.,2010
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献