Development of a Microfluidic Chip System with Giant Magnetoresistance Sensor for High-Sensitivity Detection of Magnetic Nanoparticles in Biomedical Applications

Author:

Ger Tzong-Rong1ORCID,Wu Pei-Sheng1,Wang Wei-Jie12,Chen Chiung-An3ORCID,Abu Patricia Angela R.4ORCID,Chen Shih-Lun5ORCID

Affiliation:

1. Department of Biomedical Engineering, Chung Yuan Christian University, Chung-Li 320314, Taiwan

2. Division of Nephrology, Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 115204, Taiwan

3. Department of Electrical Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan

4. Department of Information Systems and Computer Science, Ateneo de Manila University, Quezon City 1108, Philippines

5. Department of Electronic Engineering, Chung Yuan Christian University, Taoyuan City 320314, Taiwan

Abstract

Magnetic nanoparticles (MNPs) have been widely utilized in the biomedical field for numerous years, offering several advantages such as exceptional biocompatibility and diverse applications in biology. However, the existing methods for quantifying magnetic labeled sample assays are scarce. This research presents a novel approach by developing a microfluidic chip system embedded with a giant magnetoresistance (GMR) sensor. The system successfully detects low concentrations of MNPs with magnetic particle velocities of 20 mm/s. The stray field generated by the magnetic subject flowing through the microchannel above the GMR sensor causes variations in the signals. The sensor’s output signals are appropriately amplified, filtered, and processed to provide valuable indications. The integration of the GMR microfluidic chip system demonstrates notable attributes, including affordability, speed, and user-friendly operation. Moreover, it exhibits a high detection sensitivity of 10 μg/μL for MNPs, achieved through optimizing the vertical magnetic field to 100 Oe and the horizontal magnetic field to 2 Oe. Additionally, the study examines magnetic labeled RAW264.7 cells. This quantitative detection of magnetic nanoparticles can have applications in DNA concentration detection, protein concentration detection, and other promising areas of research.

Funder

Ministry of Science and Technology

Publisher

MDPI AG

Subject

Clinical Biochemistry,General Medicine,Analytical Chemistry,Biotechnology,Instrumentation,Biomedical Engineering,Engineering (miscellaneous)

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