Affiliation:
1. Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
Abstract
β-adrenoreceptors (ARs) are members of the superfamily of G-protein-coupled receptors (GPCRs), and are activated by catecholamines, such as epinephrine and norepinephrine. Three subtypes of β-ARs (β1, β2, and β3) have been identified with different distributions among ocular tissues. Importantly, β-ARs are an established target in the treatment of glaucoma. Moreover, β-adrenergic signaling has been associated with the development and progression of various tumor types. Hence, β-ARs are a potential therapeutic target for ocular neoplasms, such as ocular hemangioma and uveal melanoma. This review aims to discuss the expression and function of individual β-AR subtypes in ocular structures, as well as their role in the treatment of ocular diseases, including ocular tumors.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference254 articles.
1. A study of the adrenotropic receptors;Ahlquist;Am. J. Physiol.,1948
2. Wikberg-Matsson, A. (2001). α1- and α2-Adrenoceptors in the Eye: Pharmacological and Functional Characterization. [Ph.D. Thesis, Acta Universitatis Upsaliensis].
3. Ruan, Y., Böhmer, T., Jiang, S., and Gericke, A. (2020). The Role of Adrenoceptors in the Retina. Cells, 9.
4. Beta-adrenergic receptors, from their discovery and characterization through their manipulation to beneficial clinical application;Wachter;Cardiology,2012
5. Detailed insight on β-adrenoceptors as therapeutic targets;Velmurugan;Biomed. Pharmacother. Biomed. Pharmacother.,2019
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