IGFBP-6 Network in Chronic Inflammatory Airway Diseases and Lung Tumor Progression

Author:

Venuto Santina1ORCID,Coda Anna Rita Daniela1,González-Pérez Ruperto23ORCID,Laselva Onofrio4,Tolomeo Doron5,Storlazzi Clelia Tiziana5,Liso Arcangelo1ORCID,Conese Massimo4ORCID

Affiliation:

1. Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy

2. Allergy Department, Hospital Universitario de Canarias, 38320 Tenerife, Spain

3. Severe Asthma Unit, Hospital Universitario de Canarias, 38320 Tenerife, Spain

4. Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy

5. Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, 70125 Bari, Italy

Abstract

The lung is an accomplished organ for gas exchanges and directly faces the external environment, consequently exposing its large epithelial surface. It is also the putative determinant organ for inducing potent immune responses, holding both innate and adaptive immune cells. The maintenance of lung homeostasis requires a crucial balance between inflammation and anti-inflammation factors, and perturbations of this stability are frequently associated with progressive and fatal respiratory diseases. Several data demonstrate the involvement of the insulin-like growth factor (IGF) system and their binding proteins (IGFBPs) in pulmonary growth, as they are specifically expressed in different lung compartments. As we will discuss extensively in the text, IGFs and IGFBPs are implicated in normal pulmonary development but also in the pathogenesis of various airway diseases and lung tumors. Among the known IGFBPs, IGFBP-6 shows an emerging role as a mediator of airway inflammation and tumor-suppressing activity in different lung tumors. In this review, we assess the current state of IGFBP-6’s multiple roles in respiratory diseases, focusing on its function in the inflammation and fibrosis in respiratory tissues, together with its role in controlling different types of lung cancer.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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