Using Optogenetics to Model Cellular Effects of Alzheimer’s Disease

Author:

Tiwari Prabhat1ORCID,Tolwinski Nicholas S.23ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USA

2. Division of Science, Yale-NUS College, Singapore 138527, Singapore

3. Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore

Abstract

Across the world a dementia case is diagnosed every three seconds. Alzheimer’s disease (AD) causes 50–60% of these cases. The most prominent theory for AD correlates the deposition of amyloid beta (Aβ) with the onset of dementia. Whether Aβ is causative remains unclear due to findings such as the recently approved drug Aducanumab showing effective clearance of Aβ, but not improving cognition. New approaches for understanding Aβ function, are therefore necessary. Here we discuss the application of optogenetic techniques to gain insight into AD. Optogenetics, or genetically encoded, light-dependent on/off switches, provides precise spatiotemporal control to regulate cellular dynamics. This precise control over protein expression and oligomerization or aggregation could provide a better understanding of the etiology of AD.

Funder

Ministry of Education

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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