Tranexamic Acid (TXA) for the Hemostatic Treatment of Post-Partum Hemorrhage (PPH): What Key Points Have We Learnt After All These Years?

Author:

Peitsidis Panagiotis1ORCID,Iavazzo Christos2,Gkegkes Ioannis D.34ORCID,Laganà Antonio Simone5ORCID,Makridima Sophia1,Tsikouras Panagiotis6

Affiliation:

1. Department of Obstetrics and Gynecology, Helena Venizelou Hospital, 11521 Athens, Greece

2. Gynaecological Oncology Department, Metaxa Cancer Hospital, 18537 Piraeus, Greece

3. Athens Colorectal Laboratory, 11528 Athens, Greece

4. Department of Colorectal Surgery, Royal Devon University Healthcare NHS Foundation Trust, Exeter EX2 5DW, UK

5. Unit of Obstetrics and Gynecology, “Paolo Giaccone” Hospital, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy

6. Department of Obstetrics and Gynecology, The Democritus University of Thrace, 68100 Alexandroupolis, Greece

Abstract

Post-partum bleeding or post-partum hemorrhage (PPH) is often defined as the loss of more than 500 mL of blood after vaginal delivery or 1000 mL of blood after cesarean section following the delivery of a child [...]

Publisher

MDPI AG

Subject

General Medicine

Reference26 articles.

1. Global causes of maternal death: A WHO systematic analysis;Say;Lancet Glob. Health,2014

2. WHO Expert Committee (2011). The selection and use of essential medicines (including the 17th WHO model list of essential medicines). WHO Tech. Rep. Ser., 2011, 1–249.

3. Prevention and Management of Postpartum Haemorrhage: Green-top Guideline No. 52;Mavrides;BJOG,2017

4. Hemostatic drugs;Mannucci;NEJM,1998

5. Amino-methyl-cyclohexane-carboxylic acid: AMCHA. A new potent inhibitor of fibrinolysis;Okamoto;Keio J. Med.,1962

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