3D-QSAR Studies on a Series of Dihydroorotate Dehydrogenase Inhibitors: Analogues of the Active Metabolite of Leflunomide

Author:

Li Shun-Lai,He Mao-Yu,Du Hong-Guang

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference22 articles.

1. Pyrimidine nucleotide biosynthesis in animals: Genes, enzymes, and regulation of UMP biosynthesis;Jones;Ann. Rev. Biochem,1980

2. Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts;Nagy;Proc. Natl. Acad. Sci. USA,1992

3. Biochemical targets for malaria chemotherapy;Tamta;Curr. Res. Inf. Pharm. Sci,2003

4. Helicobacter pylori-selective antibacterials based on inhibition of pyrimidine biosynthesis;Copeland;J. Biol. Chem,2000

5. Dihydroorotate dehydrogenase is a target for the biological effects of leflunomide;Morand;Transplant. Proc,1996

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