Molecular Mechanism of Resveratrol and Its Therapeutic Potential on Female Infertility

Author:

Podgrajsek Rebeka1ORCID,Ban Frangez Helena12ORCID,Stimpfel Martin12ORCID

Affiliation:

1. Department of Human Reproduction, Division of Obstetrics and Gynecology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia

2. Medical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia

Abstract

Resveratrol is a polyphenol present in various plant sources. Studies have reported numerous potential health benefits of resveratrol, exhibiting anti-aging, anti-inflammatory, anti-microbial, and anti-carcinogenic activity. Due to the reported effects, resveratrol is also being tested in reproductive disorders, including female infertility. Numerous cellular, animal, and even human studies were performed with a focus on the effect of resveratrol on female infertility. In this review, we reviewed some of its molecular mechanisms of action and summarized animal and human studies regarding resveratrol and female infertility, with a focus on age-related infertility, polycystic ovary syndrome, and endometriosis.

Publisher

MDPI AG

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