Intestinal Microbiota and Its Effect on Vaccine-Induced Immune Amplification and Tolerance-Reference-Cited by-同舟云学术

Intestinal Microbiota and Its Effect on Vaccine-Induced Immune Amplification and Tolerance

Published:2024-08-01 Issue:8 Volume:12 Page:868
ISSN:2076-393X
Container-title:Vaccines
language:en
Short-container-title:Vaccines

Author:

Liu Yixin¹²,Zhou Jianfeng²,Yang Yushang²,Chen Xiangzheng³,Chen Longqi²,Wu Yangping¹⁴

Affiliation:

1. Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China

2. Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China

3. Department of Liver Surgery & Liver Transplantation, West China Hospital, Sichuan University, Chengdu 610041, China

4. State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu 610041, China

Abstract

This review provides the potential of intestinal microbiota in vaccine design and application, exploring the current insights into the interplay between the intestinal microbiota and the immune system, with a focus on its intermediary function in vaccine efficacy. It summarizes families and genera of bacteria that are part of the intestinal microbiota that may enhance or diminish vaccine efficacy and discusses the foundational principles of vaccine sequence design and the application of gut microbial characteristics in vaccine development. Future research should further investigate the use of multi-omics technologies to elucidate the interactive mechanisms between intestinal microbiota and vaccine-induced immune responses, aiming to optimize and improve vaccine design.

Funder

National Natural Science Foundation of China

1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University

Basic Research Projects of Qinghai Provincial Department of Science and Technology

Publisher

MDPI AG

Link

https://www.mdpi.com/2076-393X/12/8/868/pdf

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