Abstract
Multiple vaccines may prevent meningitis and encephalitis (M/E). In China, the meningococcal vaccine and Japanese encephalitis vaccine (JEV) have been included in the expanded program of immunization (EPI). The pneumococcal vaccine, Haemophilus influenzae type b (Hib) vaccine, rotavirus vaccine, and enterovirus 71 (EV-71) vaccine are non-EPI vaccines and are self-paid. We aim to investigate the uptake of these M/E vaccines in children and the related knowledge and health beliefs among family caregivers. A total of 1011 family caregivers with children aged 1–6 years in Shanghai, China were included in the study. The uptake of the pneumococcal vaccine, Hib-containing vaccine, rotavirus vaccine, and EV-71 vaccine remained at 44.0–48.1% in children, compared with the higher uptake of the meningococcal vaccine (88.8%) and JEV (87.1%). Moreover, family caregivers had limited knowledge on the M/E pathogens and possible vaccines. Their health beliefs were moderate to high. Then, a health belief model (HBM) and a structural equation model were established. The uptake of four non-EPI vaccines was significantly influenced by family income (β = 0.159), knowledge (β = 0.354), self-efficacy (β = 0.584), and perceived susceptibility (β = 0.212) within an HBM. Therefore, it warrants further improving the uptake rate for these non-EPI vaccines to prevent potential M/E in children. A specific health promotion may empower the caregivers’ decision-making on childhood vaccination.
Subject
Pharmacology (medical),Infectious Diseases,Drug Discovery,Pharmacology,Immunology
Reference51 articles.
1. Global, regional, and national burden of neurological disorders, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016;Feigin;Lancet Neurol.,2019
2. Understanding the etiology and epidemiology of meningitis and encephalitis: Now and into the future;Redenbaugh;Lancet Reg. Health. West. Pac.,2022
3. Childhood encephalitis in the Greater Mekong region (the SouthEast Asia Encephalitis Project): A multicentre prospective study;Pommier;Lancet Glob. Health,2022
4. Ai, J., Xie, Z., Liu, G., Chen, Z., Yang, Y., Li, Y., Chen, J., Zheng, G., and Shen, K. (2017). Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: A multicentre prospective study. BMC Infect. Dis., 17.
5. Long-term outcomes of infective encephalitis in children: A systematic review and meta-analysis;Khandaker;Dev. Med. Child Neurol.,2016