mRNA-Based Vaccine for COVID-19: They Are New but Not Unknown!-Reference-Cited by-同舟云学术

mRNA-Based Vaccine for COVID-19: They Are New but Not Unknown!

Published:2023-02-22 Issue:3 Volume:11 Page:507
ISSN:2076-393X
Container-title:Vaccines
language:en
Short-container-title:Vaccines

Author:

Chavda Vivek P.¹^ORCID,Jogi Gargi¹,Dave Srusti²,Patel Bhoomika M.³^ORCID,Vineela Nalla Lakshmi⁴,Koradia Krishna⁵

Affiliation:

1. Department of Pharmaceutics and Pharmaceutical Technology, L M College of Pharmacy, Ahmedabad 380009, India

2. Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad 382481, India

3. School of Medico-legal Studies, National Forensic Sciences University, Gandhinagar 382007, India

4. Department of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram 522302, India

5. Department of Pharmaceutics, Saurashtra University, Rajkot 360005, India

Abstract

mRNA vaccines take advantage of the mechanism that our cells use to produce proteins. Our cells produce proteins based on the knowledge contained in our DNA; each gene encodes a unique protein. The genetic information is essential, but cells cannot use it until mRNA molecules convert it into instructions for producing specific proteins. mRNA vaccinations provide ready-to-use mRNA instructions for constructing a specific protein. BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) both are newly approved mRNA-based COVID-19 vaccines that have shown excellent protection and efficacy. In total, there are five more mRNA-based vaccine candidates for COVID-19 under different phases of clinical development. This review is specifically focused on mRNA-based vaccines for COVID-19 covering its development, mechanism, and clinical aspects.

Publisher

MDPI AG

Subject

Pharmacology (medical),Infectious Diseases,Drug Discovery,Pharmacology,Immunology

Link

https://www.mdpi.com/2076-393X/11/3/507/pdf

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