Antibody-Dependent Respiratory Burst against Plasmodium falciparum Merozoites in Individuals Living in an Area with Declining Malaria Transmission-Reference-Cited by-同舟云学术

Antibody-Dependent Respiratory Burst against Plasmodium falciparum Merozoites in Individuals Living in an Area with Declining Malaria Transmission

Published:2024-02-16 Issue:2 Volume:12 Page:203
ISSN:2076-393X
Container-title:Vaccines
language:en
Short-container-title:Vaccines

Author:

Mutemi Doreen D.¹²³^ORCID,Tuju James³,Ogwang Rodney³,Nyamako Lydia³,Wambui Kennedy M.³⁴,Cruz Ivette R.⁵,Villner Pär⁵,Yman Victor¹⁶^ORCID,Kinyanjui Samson M.³⁷⁸⁹,Rooth Ingegerd¹¹⁰,Ngasala Billy²¹¹^ORCID,Färnert Anna¹¹²,Osier Faith H. A.³¹³¹⁴^ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, 171 77 Stockholm, Sweden

2. Department of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam 11102, Tanzania

3. Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute–Wellcome Trust Research Programme, Kilifi 80108, Kenya

4. Epidemiology and Biostatistics Division, School of Public Health, University of the Witwatersrand, Johannesburg 2000, South Africa

5. Division of Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden

6. Department of Infectious Diseases, Södersjukhuset, 118 61 Stockholm, Sweden

7. Pwani University Bioscience Research Centre, Pwani University, Kilifi 80108, Kenya

8. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LG, UK

9. School of Business Studies, Strathmore University, Nairobi 0200, Kenya

10. Nyamisati Malaria Research Group, Pwani 61621, Tanzania

11. Department of Women’s and Children’s Health, International Maternal and Child Health, Uppsala University, 751 05 Uppsala, Sweden

12. Department of Infectious Diseases, Karolinska University Hospital, 171 76 Stockholm, Sweden

13. Centre of Infectious Diseases, Heidelberg University Hospital, 69120 Heidelberg, Germany

14. Department of Life Sciences, Imperial College London, London SW7 2AZ, UK

Abstract

Malaria transmission intensity affects the development of naturally acquired immunity to malaria. An absolute correlate measure of protection against malaria is lacking. However, antibody-mediated functions against Plasmodium falciparum correlate with protection against malaria. In children, antibody-mediated functions against P. falciparum decline with reduced exposure. It is unclear whether adults maintain antibody-mediated functions as malaria transmission declines. This study assessed antibody-dependent respiratory burst (ADRB) in individuals from an area with declining malaria transmission. In an age-matched analysis, we compare ADRB activity during high versus low malaria transmission periods. Age significantly predicted higher ADRB activity in the high (p < 0.001) and low (p < 0.001) malaria transmission periods. ADRB activity was higher during the high compared to the low malaria transmission period in older children and adults. Only older adults during the high malaria transmission period had their median ADRB activity above the ADRB cut-off. Ongoing P. falciparum infection influenced ADRB activity during the low (p = 0.01) but not the high (p = 0.29) malaria transmission period. These findings propose that naturally acquired immunity to P. falciparum is affected in children and adults as malaria transmission declines, implying that vaccines will be necessary to induce and maintain protection against malaria.

Funder

U.K. Government

NIHR Global Health Research Unit Tackling Infections to Benefit Africa

Alexander von Humboldt Foundation

EDCTP Senior Fellowship

Develop African Research Leaders (IDeAL)—Wellcome Trust grant

Swedish Research Council Developmental Grants

BigFc project

Publisher

MDPI AG

Link

https://www.mdpi.com/2076-393X/12/2/203/pdf

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