Affiliation:
1. Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
2. Beijing Key Laboratory for HIV/AIDS Research, Clinical and Research, Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
3. Center of Integrative Medicine, Peking University Ditan Teaching Hospital, Beijing 100015, China
Abstract
Current knowledge regarding the long-term humoral response of people infected with human immunodeficiency virus to the third dose of inactivated coronavirus disease (COVID-19) vaccine is incomplete. As a result, concerns remain about the safety and efficacy of the vaccination. To improve our understanding of the safety and immunogenicity of the COVID-19 inactivated vaccine booster in people living with HIV (PLWH), a prospective study was conducted on participants who had not yet received a third dose of the COVID-19 inactivated vaccine, had no history of SARS-CoV-2 infection, and had received a second dose of the vaccine more than six months prior. The primary safety outcomes included the incidence of adverse reactions, changes in CD4+ T-cell count, viral load, blood routine examination, liver and kidney function examination, blood sugar, and blood lipid examination. The pseudovirus-neutralizing antibody responses to the D614G variant, Delta variant, and Omicron variants BA.5 and BF.7 were evaluated before vaccination, 14 days, 28 days, 3 months, and 6 months after vaccination to evaluate the immune response of PLWH to the injection of inactivated vaccine booster and the safety of the vaccine. In conclusion, COVID-19 vaccine booster shots were effective in PLWH, resulting in an increase in the number of CD4+ T-cells, neutralizing antibodies that lasted up to six months, and higher levels of neutralizing antibodies lasting approximately 3 months. However, the vaccine protection against the two variants of BA.5 and BF.7 was significantly lower than that of D614G and Delta.
Funder
Natural Science Foundation of Beijing
Dengfeng Talent Support Program of Beijing Municipal Administration of Hospitals
Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine
Subject
Pharmacology (medical),Infectious Diseases,Drug Discovery,Pharmacology,Immunology
Cited by
2 articles.
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