Tip Lesion Most Frequent FSGS Variant Related to COVID-19 Vaccine: Two Case Reports and Literature Review-Reference-Cited by-同舟云学术

Tip Lesion Most Frequent FSGS Variant Related to COVID-19 Vaccine: Two Case Reports and Literature Review

Published:2024-01-08 Issue:1 Volume:12 Page:62
ISSN:2076-393X
Container-title:Vaccines
language:en
Short-container-title:Vaccines

Author:

Araújo Emmy Marjorie Carvalho de¹,Campos Marcos Adriano Garcia²,Sodré Andressa Monteiro¹,Holanda Maria Izabel de³,Hagemann Rodrigo⁴,Teixeira Júnior Antonio Augusto Lima⁵^ORCID,Salgado Filho Natalino¹,Neves Precil Diego Miranda de Menezes⁶,Silva Gyl Eanes Barros¹⁷^ORCID

Affiliation:

1. Faculty of Medicine, Federal University of Maranhão, Gonçalves Dias Square, São Luís 65020-240, Brazil

2. Clinical Hospital of Botucatu Medical School, São Paulo State University, Professor Mário Rubens Guimarães Montenegro Avenue, Botucatu 18618-687, Brazil

3. Bonsucesso Federal Hospital, Londres Avenue, Rio de Janeiro 21041-020, Brazil

4. Clinical Hospital Complex, Federal University of Paraná, General Carneiro Street, Curitiba 80060-900, Brazil

5. Departament of Genetics, Ribeirão Preto Medical School, University of São Paulo, Bandeirantes Avenue, Ribeirão Preto 14040-900, Brazil

6. Clinical Hospital, University of São Paulo, Dr. Ovídio Pires de Campos Street, São Paulo 05403-010, Brazil

7. Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, Bandeirantes Avenue, Ribeirão Preto 14040-900, Brazil

Abstract

Large-scale COVID-19 vaccination has been one of the most effective strategies to control the spread of the SARS-CoV-2 virus. However, several cases of glomerular injury related to the COVID-19 vaccine have been described in the literature. We report two cases of a tip lesion variant of focal segmental glomerulosclerosis (FSGS), which presented with significant proteinuria and improved after immunosuppression. In our literature review, the tip lesion variant of FSGS is currently the most frequent variant associated with vaccination against COVID-19. Prognosis is favorable and without significant alterations in the tubulointerstitial or vascular compartments. Adverse effects of vaccines need to be recognized early and will help us to understand the immune and pathological mechanisms of kidney damage.

Publisher

MDPI AG

Subject

Pharmacology (medical),Infectious Diseases,Drug Discovery,Pharmacology,Immunology

Link

https://www.mdpi.com/2076-393X/12/1/62/pdf

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