The Transmission Dynamics of a Compartmental Epidemic Model for COVID-19 with the Asymptomatic Population via Closed-Form Solutions

Author:

Naz RehanaORCID,Torrisi MarianoORCID

Abstract

Unlike previous viral diseases, COVID-19 has an “asymptomatic” group that has no symptoms but can still spread the disease to others at the same rate as symptomatic patients who are infected. In the literature, the mass action or standard incidence rates are considered for compartmental models with asymptomatic compartment for studying the transmission dynamics of COVID-19, but the quarantined adjusted incidence rate is not. To bridge this gap, we developed a Susceptible Asymptomatic Infectious Quarantined (SAIQ) model with a Quarantine-Adjusted (QA) incidence to investigate the emergence and containment of COVID-19. COVID-19 models are investigated using various methods, but only a few studies take into account closed-form solutions. The knowledge of closed-form solutions simplifies the construction of the various epidemic indicators that describe the epidemic phenomenon and makes the sensitivity analysis to variations in the data under consideration possible. The closed-form solutions of the systems of four nonlinear first-order ordinary differential equations (ODEs) are established. The Epidemic Peak (EP), Force of Infection (FOI) and Rate of Infection (ROI) are the important indicators for the control and prevention of disease. We examined these indicators using closed-form solutions and particular parameter values. Different disease control scenarios are thoroughly examined. The four scenarios to analyze COVID-19 propagation and containment are (i) lockdown, (ii) quarantine and other preventative measures, (iii) stabilizing the basic reproduction rate to a level where the pandemic can be contained and (iv) containing the epidemic through an appropriate combination of lockdown, quarantine and other preventative measures.

Publisher

MDPI AG

Subject

Pharmacology (medical),Infectious Diseases,Drug Discovery,Pharmacology,Immunology

Reference34 articles.

1. A contribution to the mathematical theory of epidemics;Kermack;R. Soc. Lond. A,1927

2. Prevalence of asymptomatic SARS-CoV-2 infection: A narrative review;Oran;Ann. Intern. Med.,2020

3. COVID-19: Identifying and isolating asymptomatic people helped eliminate virus in Italian village;Day;BMJ Br. Med. J. Online,2020

4. A model for the emergence of drug resistance in the presence of asymptomatic infections;Robinson;Math. Biosci.,2013

5. COVID-19: Is it safe now? Study of asymptomatic infection spread and quantity risk based on SAIR model;Ying;Chaos Solitons Fractals X,2021

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3