Caspase-1 Dependent IL-1β Secretion and Antigen-Specific T-Cell Activation by the Novel Adjuvant, PCEP

Author:

Awate Sunita,Eng Nelson,Gerdts Volker,Babiuk Lorne,Mutwiri George

Publisher

MDPI AG

Subject

Pharmacology (medical),Infectious Diseases,Drug Discovery,Pharmacology,Immunology

Reference32 articles.

1. Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminium hydroxide: Effect on antigen uptake and antigen presentation;Mannhalter;Clin. Exp. Immunol.,1985

2. Mechanisms of action by immunologic adjuvants;Osebold;J. Am. Vet. Med. Assoc.,1982

3. Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling;Brewer;J. Immunol.,1999

4. Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling

5. Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

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