The Importance of Natural and Acquired Immunity to SARS-CoV-2 Infection in Patients on Peritoneal Dialysis
Author:
Baralić Marko12ORCID, Laušević Mirjana12, Ćujić Danica3ORCID, Bontić Ana12, Pavlović Jelena12, Brković Voin12, Kezić Aleksandra12, Mihajlovski Kristina4ORCID, Hadži Tanović Lara2, Assi Milošević Iman2, Lukić Jovana1, Gnjatović Marija3, Todorović Aleksandra3, Stojanović Nikola M.5ORCID, Jovanović Dijana12, Radović Milan12
Affiliation:
1. Faculty of Medicine, University of Belgrade, Doktora Subotića Starijeg 8, 11000 Belgrade, Serbia 2. Clinic of Nephrology, University Clinical Centre of Serbia (UCCS), Pasterova 2, 11000 Belgrade, Serbia 3. Institute for the Application of Nuclear Energy (INEP), University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia 4. Department of Environmental and Occupational Health, University of Nevada, Las Vegas, NV 89154, USA 5. Department of Physiology, Faculty of Medicine, University of Niš, Bulevar Zorana Đinđića 81, 18000 Niš, Serbia
Abstract
The pandemic caused by the SARS-CoV-2 virus had a great impact on the population of patients treated with peritoneal dialysis (PD). This study demonstrates the impact of infection and vaccination in 66 patients treated with PD and their outcomes during a 6-month follow-up. This is the first research that has studied the dynamics of anti-SARS-CoV-2 IgG in serum and effluent. In our research, 57.6% of PD patients were vaccinated, predominantly with Sinopharm (81.6%), which was also the most frequently administered vaccine in the Republic of Serbia at the beginning of immunization. During the monitoring period, the level of anti-SARS-CoV-2 IgG antibodies in the PD patients had an increasing trend in serum. In the group of vaccinated patients with PD, anti-SARS-CoV-2 IgG antibodies had an increasing trend in both serum and effluent, in contrast to non-vaccinated patients, where they decreased in effluent regardless of the trend of increase in serum, but statistical significance was not reached. In contrast to vaccinated (immunized) patients who did not acquire infection, the patients who only underwent the COVID-19 infection, but were not immunized, were more prone to reinfection upon the outbreak of a new viral strain, yet without severe clinical presentation and with no need for hospital treatment.
Funder
Ministry of Science, Technological Development and Innovation of Serbia Ministry of Education, Science and Technological Development of the Republic of Serbi
Subject
Pharmacology (medical),Infectious Diseases,Drug Discovery,Pharmacology,Immunology
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