Affiliation:
1. Science and Engineering of Materials Graduate Program, Laboratory of Chemical Engineering, Federal University of Pampa, P.O. Box 1650, Bagé 96413170, RS, Brazil
2. Science and Engineering of Materials Graduate Program, Laboratory of Microbiology and Food Toxicology, Federal University of Pampa, P.O. Box 1650, Bagé 96413170, RS, Brazil
Abstract
The biggest challenge for scientists is to create an ideal wound dressing that should be non-toxic, biocompatible, and biodegradable, providing optimal conditions for the most effective regeneration process. Biomaterials loaded with plant-derived compounds show better biocompatibility and biological properties, ensuring a faster tissue repair process. In order to develop membranes with good mechanical properties and anti-bacterial properties, the objective of this work describes the synthesis of a chitosan-based membrane added with olive leaf extract as an active principle with potential for topical application. The material developed was characterized in terms of morphology, physical, chemical, and mechanical properties, and the anti-bacterial capacity of the membranes. The results indicated that the developed membrane has good potential for use as a wound dressing, as it presented mechanical properties (30.17 ± 8.73 MPa) and fluid draining capacity (29.31 ± 1.65 g·m−2·h−1) adequacy. In addition, the antimicrobial activity analysis revealed the active membrane potential against E. coli and S. aureus reaching 9.9 mm and 9.1 mm, respectively, in inhibition zones, the most common bacteria in skin wounds. Therefore, all the results indicate that the developed membrane presents viable characteristics for the use of wound dressing.
Funder
FAPERGS
CNPq
Coordination of Improvement of Higher-Level Personnel—Brazil
Subject
Computer Networks and Communications,Hardware and Architecture,Software
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