Role of the G Protein-Coupled Receptors in Cancer and Stromal Cells: From Functions to Novel Therapeutic Perspectives

Author:

Lappano Rosamaria1ORCID,Maggiolini Marcello1ORCID

Affiliation:

1. Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy

Abstract

G protein-coupled receptors (GPCRs) are transmembrane signal transducers that regulate a plethora of physiological and pathological processes [...]

Publisher

MDPI AG

Subject

General Medicine

Reference46 articles.

1. Trends in GPCR Drug Discovery: New Agents, Targets and Indications;Hauser;Nat. Rev. Drug Discov.,2017

2. G Protein-Coupled Receptor Signaling: Transducers and Effectors;Jiang;Am. J. Physiol. Cell Physiol.,2022

3. G Protein Beta Gamma Subunits;Clapham;Annu. Rev. Pharmacol. Toxicol.,1997

4. G Protein βγ Subunits: Central Mediators of G Protein-Coupled Receptor Signaling;Smrcka;Cell. Mol. Life Sci.,2008

5. Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling;Ferguson;Pharmacol. Rev.,2001

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