Affiliation:
1. School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA
Abstract
The evolutionary conserved WNT signaling pathway orchestrates numerous complex biological processes during development and is critical to the maintenance of tissue integrity and homeostasis in the adult. As it relates to the central nervous system, WNT signaling plays several roles as it relates to neurogenesis, synaptic formation, memory, and learning. Thus, dysfunction of this pathway is associated with multiple diseases and disorders, including several neurodegenerative disorders. Alzheimer’s disease (AD) is characterized by several pathologies, synaptic dysfunction, and cognitive decline. In this review, we will discuss the various epidemiological, clinical, and animal studies that demonstrate a precise link between aberrant WNT signaling and AD-associated pathologies. In turn, we will discuss the manner in which WNT signaling influences multiple molecular, biochemical, and cellular pathways upstream of these end-point pathologies. Finally, we will discuss how merging tools and technologies can be used to generate next generation cellular models to dissect the relationship between WNT signaling and AD.
Funder
National Institutes of Health
Alzheimer’s Association
Reference283 articles.
1. 2022 Alzheimer’s Disease Facts and Figures;Harper;Alzheimers Dement.,2022
2. Neuropathological Alterations in Alzheimer Disease;Frosch;Cold Spring Harb. Perspect. Med.,2011
3. Mehta, R.I., and Mehta, R.I. (2023). The Vascular-Immune Hypothesis of Alzheimer’s Disease. Biomedicines, 11.
4. Alzheimer’s Disease Pathologic Cascades: Who Comes First, What Drives What;Swerdlow;Neurotox. Res.,2012
5. Apolipoprotein E and Alzheimer Disease: Risk, Mechanisms and Therapy;Liu;Nat. Rev. Neurol.,2013
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献