An Updated Review of Hypertrophic Scarring-Reference-Cited by-同舟云学术

An Updated Review of Hypertrophic Scarring

Published:2023-02-21 Issue:5 Volume:12 Page:678
ISSN:2073-4409
Container-title:Cells
language:en
Short-container-title:Cells

Author:

Mony Manjula P.¹,Harmon Kelly A.¹^ORCID,Hess Ryan¹,Dorafshar Amir H.¹^ORCID,Shafikhani Sasha H.²³^ORCID

Affiliation:

1. Department of Surgery, Division of Plastic & Reconstructive Surgery, Rush University Medical Center, Chicago, IL 60612, USA

2. Department of Medicine, Division of Hematology and Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL 60612, USA

3. Cancer Center, Rush University Medical Center, Chicago, IL 60612, USA

Abstract

Hypertrophic scarring (HTS) is an aberrant form of wound healing that is associated with excessive deposition of extracellular matrix and connective tissue at the site of injury. In this review article, we provide an overview of normal (acute) wound healing phases (hemostasis, inflammation, proliferation, and remodeling). We next discuss the dysregulated and/or impaired mechanisms in wound healing phases that are associated with HTS development. We next discuss the animal models of HTS and their limitations, and review the current and emerging treatments of HTS.

Funder

National Institutes of Health

Publisher

MDPI AG

Subject

General Medicine

Link

https://www.mdpi.com/2073-4409/12/5/678/pdf

Reference191 articles.

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3. Diagnosis and treatment of keloids and hypertrophic scars—Japan scar workshop consensus document 2018;Ogawa;Burn. Trauma,2019