The Multifaceted Role of Annexin A1 in Viral Infections-Reference-Cited by-同舟云学术

The Multifaceted Role of Annexin A1 in Viral Infections

Published:2023-04-11 Issue:8 Volume:12 Page:1131
ISSN:2073-4409
Container-title:Cells
language:en
Short-container-title:Cells

Author:

Resende Filipe¹²,Araújo Simone de²,Tavares Luciana Pádua³^ORCID,Teixeira Mauro Martins²⁴,Costa Vivian Vasconcelos¹²

Affiliation:

1. Post-Graduation Program of Cell Biology, Department of Morphology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil

2. Center for Research and Development of Drugs, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil

3. Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA

4. Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil

Abstract

Dysregulated inflammatory responses are often correlated with disease severity during viral infections. Annexin A1 (AnxA1) is an endogenous pro-resolving protein that timely regulates inflammation by activating signaling pathways that culminate with the termination of response, clearance of pathogen and restoration of tissue homeostasis. Harnessing the pro-resolution actions of AnxA1 holds promise as a therapeutic strategy to control the severity of the clinical presentation of viral infections. In contrast, AnxA1 signaling might also be hijacked by viruses to promote pathogen survival and replication. Therefore, the role of AnxA1 during viral infections is complex and dynamic. In this review, we provide an in-depth view of the role of AnxA1 during viral infections, from pre-clinical to clinical studies. In addition, this review discusses the therapeutic potential for AnxA1 and AnxA1 mimetics in treating viral infections.

Funder

Minas Gerais Foundation for Science

Brazilian National Science Council

FAPEMIG

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

MDPI AG

Subject

General Medicine

Link

https://www.mdpi.com/2073-4409/12/8/1131/pdf

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