Affiliation:
1. Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdaero, Sujeong-gu, Seongnam-si 13120, Republic of Korea
Abstract
Bone health is a critical aspect of overall well-being, and disorders such as osteoporosis pose significant challenges worldwide. East Asian Herbal Medicine (EAHM), with its rich history and holistic approach, offers promising avenues for enhancing bone regeneration. In this critical review article, we analyze the intricate mechanisms through which EAHM compounds modulate bone health. We explore the interplay between osteogenesis and osteoclastogenesis, dissect signaling pathways crucial for bone remodeling and highlight EAHM anti-inflammatory effects within the bone microenvironment. Additionally, we emphasize the promotion of osteoblast viability and regulation of bone turnover markers by EAHM compounds. Epigenetic modifications emerge as a fascinating frontier where EAHM influences DNA methylation and histone modifications to orchestrate bone regeneration. Furthermore, we highlight EAHM effects on osteocytes, mesenchymal stem cells and immune cells, unraveling the holistic impact in bone tissue. Finally, we discuss future directions, including personalized medicine, combinatorial approaches with modern therapies and the integration of EAHM into evidence-based practice.
Funder
Ministry of Health & Welfare, Republic of Korea
Reference113 articles.
1. Bone Cell Communication Factors Provide a New Therapeutic Strategy for Osteoporosis;Kim;Chonnam Med. J.,2020
2. Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis;Manolagas;Endocr. Rev.,2000
3. Bone Remodeling;Hadjidakis;Ann. N. Y. Acad. Sci.,2006
4. “Take My Bone Away?” Hypoxia and Bone: A Narrative Review;Hannah;J. Cell. Physiol.,2021
5. Owen, M. (1985). Lineage of Osteogenic Cells and Their Relationship to the Stromal System. Bone and Mineral Research, ScienceOpen, Inc.