Phytochemical Profiling, Antioxidant and Antimicrobial Potentials of Ethanol and Ethyl Acetate Extracts of Chamaenerion latifolium L.-Reference-Cited by-同舟云学术

Phytochemical Profiling, Antioxidant and Antimicrobial Potentials of Ethanol and Ethyl Acetate Extracts of Chamaenerion latifolium L.

Published:2024-07-27 Issue:8 Volume:17 Page:996
ISSN:1424-8247
Container-title:Pharmaceuticals
language:en
Short-container-title:Pharmaceuticals

Author:

Kozhantayeva Akmaral¹²^ORCID,Tursynova Nurgul¹,Kolpek Ainagul²,Aibuldinov Yelaman¹^ORCID,Tursynova Arailym²,Mashan Togzhan²,Mukazhanova Zhazira³,Ibrayeva Manshuk⁴,Zeinuldina Aizhan⁵^ORCID,Nurlybayeva Aisha⁶,Iskakova Zhanar¹²^ORCID,Tashenov Yerbolat¹²

Affiliation:

1. Research Institute of New Chemical Technologies, L.N. Gumilyov Eurasian National University, Satpayev Street 2, Astana 010000, Kazakhstan

2. Department of Chemistry, Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Satpayev Street 2, Astana 010000, Kazakhstan

3. Department of Chemistry, Graduate School of IT and Natural Sciences, East Kazakhstan University Named after S. Amanzholov, Ust-Kamenogorsk 010008, Kazakhstan

4. Faculty of Science and Technology, The Caspian University of Technology and Engineering Named after Sh.Yessenov, Aktau 130000, Kazakhstan

5. Department of General and Biological Chemistry, NJSC “Astana Medical University”, Astana 010000, Kazakhstan

6. Department of Chemistry and Chemical Technology, Faculty of Technology, M.Kh. Dulaty Taraz Regional University, Taraz 080000, Kazakhstan

Abstract

The study investigates the phytochemical profile, antioxidant capacity, and antimicrobial activities of ethanol (ChL-EtOH) and ethyl acetate (ChL-EtOAc) extracts from Chamaenerion latifolium L. (ChL) harvested in Kazakhstan. The ChL-EtOH extract exhibited higher total phenolic (267.48 ± 3.44 mg GAE/g DE) and flavonoid content (24.18 ± 1.06 mg QE/g DE) compared to ChL-EtOAc. HPLC-UV-ESI/MS identified key phenolic acids and flavonoids, including gallic acid, chlorogenic acid, and quercetin 3-glucoside. FT-IR analysis confirmed the presence of characteristic functional groups. Antioxidant assays revealed strong DPPH scavenging and FRAP activities, with ChL-EtOH showing superior results (IC50 = 21.31 ± 0.65 μg/mL and 18.13 ± 0.15 μg/mL, respectively). Additionally, ChL-EtOH displayed notable antimicrobial efficacy against Gram-positive and Gram-negative bacteria, as well as the fungal strain Candida albicans. These findings suggest that ethanol extraction is more efficient for isolating bioactive compounds from ChL, underscoring its potential for pharmaceutical and nutraceutical applications.

Funder

Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan

Publisher

MDPI AG

Link

https://www.mdpi.com/1424-8247/17/8/996/pdf

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