Effects of Ethanolic and Aqueous Extracts of Garcinia gardneriana Leaves in an In Vivo Experimental Model Induced by a Hyperlipidic Diet

Author:

Santo Bruna Larissa Spontoni do Espirito1,Santana Lidiani Figueiredo1ORCID,Kato Junior Wilson Hino2,Araújo Felipe de Oliveira de3,Tatara Mariana Bento4,Croda Júlio56,Bogo Danielle1,Freitas Karine de Cássia1,Guimarães Rita de Cássia Avellaneda1,Hiane Priscila Aiko1ORCID,Pott Arnildo7ORCID,Filiú Wander Fernando de Oliveira8,Faria Bernardo Bacelar de9,Figueiredo Patrícia de Oliveira10,do Nascimento Valter Aragão11ORCID,Ayres Frederico Louveira11,Bastos Paulo Roberto Haidamus de Oliveira1

Affiliation:

1. Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil

2. Graduate of Pharmaceutical Sciences, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil

3. Graduate of Electrical Engineering, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil

4. Health Science Research Laboratory, Federal University of Grande Dourados, Dourados 79804-970, Brazil

5. School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil

6. Oswaldo Cruz Foundation, Campo Grande 79074-460, Brazil

7. Laboratory of Botany, Institute of Biosciences, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil

8. Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil

9. Diagnostic Medicine Laboratory-Scapulatempo, Campo Grande 79002-17, Brazil

10. Laboratory of Pronabio (Bioactive Natural Products), Chemistry Institute, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, Brazil

11. Medical School, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil

Abstract

The study of medicinal plants, such as the genus Garcinia (Clusiaceae), in the treatment of non-communicable chronic diseases has aroused the interest of researchers. However, there are no studies in the literature that have investigated the effects of Garcinia gardneriana in experimental models of obesity for possible metabolic alterations. Swiss mice receiving a high-fat diet were supplemented with aqueous or ethanolic extract of G. gardneriana at doses of 200 or 400 mg/kg/day. It was found that there was a reduction in food consumption in experimental groups compared with the control groups, and the group supplemented with aqueous extract at a dose of 200 mg/kg/daydisplayed a reduction in weight. The results showed an increase in the values of high density lipoprotein (HDL-c), total cholesterol, triglycerides and fasting blood glucose. G. gardneriana did not protect against insulin resistance, and caused in an increase in monocyte chemoattractant protein-1 (MCP-1) concentrations and a reduction in interleukin 10 (IL-10). In addition, hepatic steatosis and microvesicular steatosis were indicated. It was revealed that, under the experimental conditions in the study, G. gardneriana did not prevent weight gain or comorbidities; that is, a different behavior was obtained from that described in the literature with regard to the medicinal potential of the Garcinia species, which is probably related to the phytochemical properties.

Funder

Federal University of Mato Grosso do Sul-UFMS/MEC-Brazil

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

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