Recombination Analysis of Non-Poliovirus Members of the Enterovirus C Species: Restriction of Recombination Events to Members of the Same 3DPol Cluster

Author:

Brouwer LiekeORCID,Benschop Kimberley S.M.,Nguyen DungORCID,Kamau Everlyn,Pajkrt Dasja,Simmonds PeterORCID,Wolthers Katja C.

Abstract

Enteroviruses (EVs) are highly prevalent viruses worldwide. Recombination is known to occur frequently in EVs belonging to species Enterovirus A, Enterovirus B, and Enterovirus C. Although many recombinant vaccine-derived poliovirus (VDPV) strains have been reported, our knowledge on recombination in non-polio EVs in the species Enterovirus C is limited. Here, we combined a dataset consisting of 11 newly generated full-length Enterovirus C sequences and 180 publicly available sequences to study recombination dynamics in non-polio EVs. To identify recombination patterns, maximum likelihood phylogenetic trees of different genomic regions were constructed, and segregation analyses were performed. Recombination was observed between members of the same 3DPol cluster, but was rarely observed between members of different clusters. We hypothesize that this restriction may have arisen through their different compartmentalization in respiratory and enteric tracts related to differences in cellular tropisms so that the opportunity to recombine may not be available.

Funder

Federation of European Microbiological Societies

Koninklijke Nederlandse Akademie van Wetenschappen

H2020 European Institute of Innovation and Technology

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

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