Laser Induced Method to Produce Curcuminoid-Silanol Thin Films for Transdermal Patches Using Irradiation of Turmeric Target

Abstract

A new possible method to produce a transdermal patch is proposed in this paper. The study refers to the pulsed laser deposition method (PLD) applied on turmeric target in order to obtain thin layers. Under high power laser irradiation of 532 nm wavelength, thin films containing curcuminoids were obtained on different substrates such as glass and quartz (laboratory investigation) and hemp fabric (practical application). Compared FTIR, SEM-EDS and LIF analyses proved that the obtained thin film chemical composition is mainly demethoxycurcumin and bisdemethoxycurcumin which is evidence that most of the curcumin from turmeric has been demethixylated during laser ablation. Silanol groups with known role into dermal reconstruction are evidenced in both turmeric target and curcuminoid thin films. UV–VIS reflection spectra show the same characteristics for all the curcuminoid thin films, indicating that the method is reproducible. The method proves to be successful for producing a composite material, namely curcuminoid transdermal patch with silanol groups, using directly turmeric as target in the thin film deposited by pulsed laser technique. Double layered patch curcuminoid—silver was produced under this study, proving compatibility between the two deposited layers. The silver layer added on curcuminoid-silanol layer aimed to increase antiseptic properties to the transdermal patch.