From Vineyard to Vision: Efficacy of Maltodextrinated Grape Pomace Extract (MaGPE) Nutraceutical Formulation in Patients with Diabetic Retinopathy

Author:

Schiano Elisabetta1ORCID,Vaccaro Sabrina2ORCID,Scorcia Vincenzo2ORCID,Carnevali Adriano2,Borselli Massimiliano2ORCID,Chisari Domenico2,Guerra Fabrizia1,Iannuzzo Fortuna3ORCID,Tenore Gian Carlo4ORCID,Giannaccare Giuseppe5ORCID,Novellino Ettore1

Affiliation:

1. Inventia Biotech-Healthcare Food Research Center s.r.l., Strada Statale Sannitica KM 20.700, 81020 Caserta, Italy

2. Department of Ophthalmology, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy

3. Department of Pharmacy, University of Chieti-Pescara G. D’Annunzio, 66100 Chieti, Italy

4. Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 59, 80131 Naples, Italy

5. Eye Clinic, Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy

Abstract

Despite recent advances, pharmacological treatments of diabetic retinopathy (DR) do not directly address the underlying oxidative stress. This study evaluates the efficacy of a nutraceutical formulation based on maltodextrinated grape pomace extract (MaGPE), an oxidative stress inhibitor, in managing DR. A 6-month, randomized, placebo-controlled clinical trial involving 99 patients with mild to moderate non-proliferative DR was conducted. The MaGPE group showed improvement in best-corrected visual acuity (BCVA) values at T3 (p < 0.001) and T6 (p < 0.01), a reduction in CRT (at T3 and T6, both p < 0.0001) and a stabilization of vascular perfusion percentage, with slight increases at T3 and T6 (+3.0% and +2.7% at T3 and T6, respectively, compared to baseline). Additionally, the levels of reactive oxygen metabolite derivatives (dROMs) decreased from 1100.6 ± 430.1 UCARR at T0 to 974.8 ± 390.2 UCARR at T3 and further to 930.6 ± 310.3 UCARR at T6 (p < 0.05 vs. T0). Similarly, oxidized low-density lipoprotein (oxLDL) levels decreased from 953.9 ± 212.4 µEq/L at T0 to 867.0 ± 209.5 µEq/L at T3 and markedly to 735.0 ± 213.7 µEq/L at T6 (p < 0.0001 vs. T0). These findings suggest that MaGPE supplementation effectively reduces retinal swelling and oxidative stress, contributing to improved visual outcomes in DR patients.

Publisher

MDPI AG

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