Aging Changes the Efficacy of Central Urocortin 2 to Induce Weight Loss in Rats
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Published:2023-05-19
Issue:10
Volume:24
Page:8992
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Kovács Dóra K.1, Eitmann Szimonetta1, Berta Gergely2, Kormos Viktória3ORCID, Gaszner Balázs4ORCID, Pétervári Erika1, Balaskó Márta1ORCID
Affiliation:
1. Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12., 7624 Pecs, Hungary 2. Department of Medical Biology, Medical School, University of Pécs, Szigeti út 12., 7624 Pecs, Hungary 3. Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12., 7624 Pecs, Hungary 4. Department of Anatomy, Medical School, University of Pécs, Szigeti út 12., 7624 Pecs, Hungary
Abstract
Middle-aged obesity and aging cachexia present healthcare challenges. Central responsiveness to body-weight-reducing mediators, e.g., to leptin, changes during aging in a way, which may promote middle-aged obesity and aging cachexia. Leptin is connected to urocortin 2 (Ucn2), an anorexigenic and hypermetabolic member of the corticotropin family. We aimed to study the role of Ucn2 in middle-aged obesity and aging cachexia. The food intake, body weight and hypermetabolic responses (oxygen consumption, core temperature) of male Wistar rats (3, 6, 12 and 18 months) were tested following intracerebroventricular injections of Ucn2. Following one central injection, Ucn2-induced anorexia lasted for 9 days in the 3-month, 14 days in the 6-month and 2 days in the 18-month group. Middle-aged 12-month rats failed to show anorexia or weight loss. Weight loss was transient (4 days) in the 3-month, 14 days in the 6-month and slight but long-lasting in the 18-month rats. Ucn2-induced hypermetabolism and hyperthermia increased with aging. The age-dependent changes in the mRNA expression of Ucn2 detected by RNAscope in the paraventricular nucleus correlated with the anorexigenic responsiveness. Our results show that age-dependent changes in Ucn2 may contribute to middle-aged obesity and aging cachexia. Ucn2 shows potential in the prevention of middle-aged obesity.
Funder
European Union’s Recovery and Resilience Facility: RRF Human Resources Development Operational Programme Medical School of the University of Pecs, Hungary National Research, Development and Innovation Fund of Hungary János Bolyai Research Scholarship of the Hungarian Academy of Sciences New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund Medical School, University of Pécs, Hungarz
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
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