Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice-Reference-Cited by-同舟云学术

Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice

Published:2023-05-18 Issue:10 Volume:24 Page:8962
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Ivlieva Alexandra L.¹²,Petritskaya Elena N.¹,Rogatkin Dmitriy A.¹,Zinicovscaia Inga³⁴⁵^ORCID,Yushin Nikita³^ORCID,Grozdov Dmitrii³^ORCID

Affiliation:

1. Institute of Higher Nervous Activity and Neurophysiology of RAS, 5A Butlerova St., 117485 Moscow, Russia

2. Moscow Regional Research and Clinical Institute named after M. F. Vladimirsky, Str. Schepkina 61/2, 129110 Moscow, Russia

3. Joint Institute for Nuclear Research, Str. Joliot-Curie 6, 141980 Dubna, Russia

4. Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, 30 Reactorului Str., MG-6, RO-76900 Bucharest-Magurele, Romania

5. Institute of Chemistry, Academiei Str. 3, MD-2028 Chisinau, Moldova

Abstract

The influence of gold nanoparticles after their prolonged oral administration to mice (during pregnancy and lactation) on spatial memory and anxiety levels in offspring was investigated. Offspring were tested in the Morris water maze and in the elevated Plus-maze. The average specific mass content of gold which crossed the blood–brain barrier was measured using neutron activation analysis and constituted 3.8 ng/g for females and 1.1 ng/g for offspring. Experimental offspring showed no differences in spatial orientation and memory compared to the control, while their anxiety levels increased. Gold nanoparticles influenced the emotional state of mice exposed to nanoparticles during prenatal and early postnatal development, but not their cognitive abilities.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/10/8962/pdf

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