Functionalization of the Surface of Porous Nickel–Titanium Alloy with Macrocyclic Compounds

Abstract

For the first time, we performed functionalization of the surface of porous titanium nickelide alloys with bambusuril[6]-based macrocyclic compounds by different methods in order to provide the basis for saturation with therapeutic agents to impart antibacterial activity and accelerate its osteogenesis. It has been shown for the first time that the vacuum modification method is preferable for bambusuril deposition, since it provides a uniform deposition of organic matter on both the outer and inner surfaces of the pores. The effect of bambusuril deposition methods on the continuity, structure, and cytocompatibility of the porous titanium nickelide surface was evaluated. In vitro tests proved high biocompatibility and low toxicity of porous TiNi treated with BU[6] under vacuum. The SEM study of the structure of the surface layer of TiNi modified with BU[6] under the vacuum method showed that BU[6] agglomerates are uniformly deposited on the inner and outer surfaces of TiNi pores, which will provide an even saturation of BU[6] cavities with various pharmaceuticals, including antibiotics and inhibitors.