Moisture Transport Coefficients Determination on a Model Pharmaceutical Tablet

Abstract

In this work, a novel methodology to determine moisture transport coefficients for MMC PH101 tablets is presented. Absolute permeability, moisture diffusion, moisture transfer, and water vapor permeability coefficients were estimated on compressed powder tablets produced with different compression pressures (20 MPa to 200 MPa with an interval of 20 MPa). The ASTM D6539 standard test was used to measure the absolute permeability. The moisture transfer coefficient was determined from measured absolute permeability. The moisture diffusion coefficient was obtained with the tablet average pore radius, which was determined with the water droplet penetration method. Descriptive and phenomenological models derived from the measurements were confronted with existing and adopted models, and a good agreement was found. The obtained models are of the function of the microstructural properties of the tablet (average pore radius and average porosity). The tablet average porosity was found to be the principal parameter that governs the behavior of the moisture transport coefficients. The findings of this study might be applicable to obtain a series of input parameters for modelling software, such as COMSOL Multiphysics®, to infer delamination, sticking, and failure propensity from the effect of moisture.