A Review of the Potential of Poly-(lactide-co-glycolide) Nanoparticles as a Delivery System for an Active Antimycobacterial Compound, 7-Methyljuglone-Reference-Cited by-同舟云学术

A Review of the Potential of Poly-(lactide-co-glycolide) Nanoparticles as a Delivery System for an Active Antimycobacterial Compound, 7-Methyljuglone

Published:2024-02-01 Issue:2 Volume:16 Page:216
ISSN:1999-4923
Container-title:Pharmaceutics
language:en
Short-container-title:Pharmaceutics

Author:

Diedericks Bianca¹^ORCID,Kok Anna-Mari¹²,Mandiwana Vusani³,Lall Namrita¹⁴⁵⁶^ORCID

Affiliation:

1. Department of Plant and Soil Sciences, University of Pretoria, Pretoria 0002, South Africa

2. Research Fellow, South African International Maritime Institute (SAIMI), Nelson Mandela University, Gqeberha 6019, South Africa

3. Chemicals Cluster, Centre for Nanostructures and Advanced Materials, Council for Scientific and Industrial Research, Pretoria 0001, South Africa

4. School of Natural Resources, University of Missouri, Columbia, MO 65211, USA

5. College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru 643001, India

6. Senior Research Fellow, Bio-Tech R&D Institute, University of the West Indies, Kingston IAU-016615, Jamaica

Abstract

7-Methyljuglone (7-MJ) is a pure compound isolated from the roots of Euclea natalensis A. DC., a shrub indigenous to South Africa. It exhibits significant promise as a potential treatment for the highly communicable disease tuberculosis (TB), owing to its effective antimycobacterial activity against Mycobacterium tuberculosis. Despite its potential therapeutic benefits, 7-MJ has demonstrated in vitro cytotoxicity against various cancerous and non-cancerous cell lines, raising concerns about its safety for consumption by TB patients. Therefore, this review focuses on exploring the potential of poly-(lactide-co-glycolic) acid (PLGA) nanoparticles as a delivery system, which has been shown to decrease in vitro cytotoxicity, and 7-MJ as an effective antimycobacterial compound.

Funder

National Research Foundation

Publisher

MDPI AG

Subject

Pharmaceutical Science

Link

https://www.mdpi.com/1999-4923/16/2/216/pdf

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