An Investigation on the Relationship between Dust Emission and Air Flow as Well as Particle Size with a Novel Containment Two-Chamber Setup

Author:

Wirth Steffen1,Schöler Martin2,Brügmann Jonas2,Leopold Claudia S.1

Affiliation:

1. Department of Pharmaceutical Technology, University of Hamburg, Bundesstr. 45, 20146 Hamburg, Germany

2. Fette Compacting GmbH, Grabauer Straße 24, 21493 Schwarzenbek, Germany

Abstract

In the present study with a novel two-chamber setup (TCS) for dustiness investigations, the relationship between pressure differences as well as air velocities and the resulting dust emissions is investigated. The dust emissions of six particle size fractions of acetaminophen at pressure differences between 0 and 12 Pa are examined. The results show that both simulated and measured air velocities increase with increasing pressure difference. Dust emissions decrease significantly with increasing pressure difference and air velocity. Fine particles cause higher dust emissions than coarse particles. A high goodness of fit is obtained with exponential and quadratic functions to describe the relationship between pressure difference and dust emission, indicating that even moderate increases in pressure may lead to a reduction in the emission. Average air velocities within the TCS simulated with Computational Fluid Dynamics are between 0.09 and 0.37 m/s, whereas those measured experimentally are between 0.09 and 0.41 m/s, both ranges corresponding to the recommended values for effective particle separation in containment systems. These results underline the ability of the novel TCS to control pressure and airflow, which is essential for reliable dust emission measurements and thus provide support for further scientific and industrial applications.

Publisher

MDPI AG

Reference55 articles.

1. International Society for Pharmaceutical Engineering (ISPE) (2017). ISPE D/A/CH Affiliate: Containment Manual, ISPE D/A/CH.

2. Frameworks and Tools for Risk Assessment of Manufactured Nanomaterials;Hristozov;Environ. Int.,2016

3. Development and Implementation of a Large-Scale HPAPI Manufacturing Process;Becker;Chim. Oggi-Chem. Today,2019

4. Ramazzini and Workers’ Health;Franco;Lancet,1999

5. Managing High-Potency Active Pharmaceutical Ingredients—A Drug Sponsor’s Guide;Wollowitz;Drug Dev. Res.,2010

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3