Cell Membrane-Coated Biomimetic Nanoparticles in Cancer Treatment

Author:

Zhang Shu12,Zhang Xiaojuan2,Gao Huan2,Zhang Xiaoqin2,Sun Lidan2,Huang Yueyan2,Zhang Jie2,Ding Baoyue2ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 214122, China

2. Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing 314001, China

Abstract

Nanoparticle-based drug delivery systems hold promise for cancer treatment by enhancing the solubility and stability of anti-tumor drugs. Nonetheless, the challenges of inadequate targeting and limited biocompatibility persist. In recent years, cell membrane nano-biomimetic drug delivery systems have emerged as a focal point of research and development, due to their exceptional traits, including precise targeting, low toxicity, and good biocompatibility. This review outlines the categorization and advantages of cell membrane bionic nano-delivery systems, provides an introduction to preparation methods, and assesses their applications in cancer treatment, including chemotherapy, gene therapy, immunotherapy, photodynamic therapy, photothermal therapy, and combination therapy. Notably, the review delves into the challenges in the application of various cell membrane bionic nano-delivery systems and identifies opportunities for future advancement. Embracing cell membrane-coated biomimetic nanoparticles presents a novel and unparalleled avenue for personalized tumor therapy.

Funder

National Natural Science Foundation of China

Basic Public Welfare Research Project of Zhejiang Province

Publisher

MDPI AG

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