Affiliation:
1. Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan
Abstract
Gummy formulations are defined as gradually or slowly released solid oral dosage forms. Risperidone is an atypical antipsychotic medication used to treat schizophrenia and autism-related irritability. This study presents the development of visually appealing, patient-tailored medicated gummies that act as a novel pharmaceutical form of Risperidone for pediatrics. In this study, two gummy bases were used, one containing Glucomannan and the other containing Gelatin as a gelling agent, where these gummy bases were loaded with coated Risperidone pellets with a controlled release layer. The final products were evaluated for their pH, viscosity, content uniformity, drug content, and dissolution profile. Both formulas showed proper rheology and met content and weight uniformity standards. The release rates for F1 and F2 in the acidic media were 25% and 11%, respectively, after 2 h. At the same time, a full-release profile for Risperidone was noticed in both formulae at pH 6.8 where the release lasts for 24 h. It can be concluded that the chewable semi-solid dosages (gummies) filled with coated pellets are suitable for pediatric patients since pediatrics have drug-related problems which can be solved using high gastro-resistance coated pellets, which also shows a proper release profile for the drug.
Funder
Jordan University of Science and Technology
Reference56 articles.
1. Head-to-head comparison of aripiprazole and risperidone in the treatment of ADHD symptoms in children with autistic spectrum disorder and ADHD: A pilot, open-label, randomized controlled study;Lamberti;Pediatr. Drugs,2016
2. Inattention, hyperactivity, and impulsivity in teenagers with intellectual disabilities, with and without autism;Bradley;Can. J. Psychiatry,2006
3. Childhood autism spectrum disorder in the Barwon region: A community based study;Icasiano;J. Paediatr. Child Health,2004
4. Autistic spectrum disorder: A child population profile;Keen;Autism,2004
5. Attention deficit hyperactivity symptoms in children with autistic disorder: A cross-sectional descriptive study;Charnsil;J. Med. Assoc. Thail.,2011