Affiliation:
1. Department of Life, Health and Environmental Science, University of L’Aquila, 67100 L’Aquila, Italy
Abstract
Neurological disorders are the second cause of death and the leading cause of disability worldwide. Unfortunately, no cure exists for these disorders, but the actual therapies are only able to ameliorate people’s quality of life. Thus, there is an urgent need to test potential therapeutic approaches. Brain organoids are a possible valuable tool in the study of the brain, due to their ability to reproduce different brain regions and maturation stages; they can be used also as a tool for disease modelling and target identification of neurological disorders. Recently, brain organoids have been used in drug-screening processes, even if there are several limitations to overcome. This review focuses on the description of brain organoid development and drug-screening processes, discussing the advantages, challenges, and limitations of the use of organoids in modeling neurological diseases. We also highlighted the potential of testing novel therapeutic approaches. Finally, we examine the challenges and future directions to improve the drug-screening process.
Reference104 articles.
1. Lima, A.A., Mridha, M.F., Das, S.C., Kabir, M.M., Islam, M.R., and Watanobe, Y. (2022). A Comprehensive Survey on the Detection, Classification, and Challenges of Neurological Disorders. Biology, 11.
2. Global, Regional, and National Burden of Neurological Disorders in 204 Countries and Territories Worldwide;Huang;J. Glob. Health,2023
3. Global, Regional, and National Burden of Neurological Disorders, 1990–2016: A Systematic Analysis for the Global Burden of Disease Study 2016;Feigin;Lancet Neurol.,2019
4. Artificial Intelligence Techniques for Automated Diagnosis of Neurological Disorders;Raghavendra;Eur. Neurol.,2019
5. Epidemiology of Neurological Diseases in Older Adults;Dumurgier;Rev. Neurol.,2020
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献