Brain Organoids: A Game-Changer for Drug Testing

Author:

Giorgi Chiara1ORCID,Lombardozzi Giorgia1ORCID,Ammannito Fabrizio1,Scenna Marta Sofia1ORCID,Maceroni Eleonora1ORCID,Quintiliani Massimiliano1,d’Angelo Michele1ORCID,Cimini Annamaria1ORCID,Castelli Vanessa1ORCID

Affiliation:

1. Department of Life, Health and Environmental Science, University of L’Aquila, 67100 L’Aquila, Italy

Abstract

Neurological disorders are the second cause of death and the leading cause of disability worldwide. Unfortunately, no cure exists for these disorders, but the actual therapies are only able to ameliorate people’s quality of life. Thus, there is an urgent need to test potential therapeutic approaches. Brain organoids are a possible valuable tool in the study of the brain, due to their ability to reproduce different brain regions and maturation stages; they can be used also as a tool for disease modelling and target identification of neurological disorders. Recently, brain organoids have been used in drug-screening processes, even if there are several limitations to overcome. This review focuses on the description of brain organoid development and drug-screening processes, discussing the advantages, challenges, and limitations of the use of organoids in modeling neurological diseases. We also highlighted the potential of testing novel therapeutic approaches. Finally, we examine the challenges and future directions to improve the drug-screening process.

Publisher

MDPI AG

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