Process-Induced Crystal Surface Anisotropy and the Impact on the Powder Properties of Odanacatib

Author:

Bade Isha1ORCID,Karde Vikram1,Schenck Luke2,Solomos Marina2,Figus Margaret3,Chen Chienhung3,Axnanda Stephanus3ORCID,Heng Jerry Y. Y.1ORCID

Affiliation:

1. Department of Chemical Engineering, South Kensington Campus, Imperial College London, London SW7 2AZ, UK

2. Oral Formulation Sciences, Merck & Co., Inc., Rahway, NJ 07065, USA

3. Analytical Research & Development, Merck & Co., Inc., Rahway, NJ 07065, USA

Abstract

Crystalline active pharmaceutical ingredients with comparable size and surface area can demonstrate surface anisotropy induced during crystallization or downstream unit operations such as milling. To the extent that varying surface properties impacts bulk powder properties, the final drug product performance such as stability, dissolution rates, flowability, and dispersibility can be predicted by understanding surface properties such as surface chemistry, energetics, and wettability. Here, we investigate the surface properties of different batches of Odanacatib prepared through either jet milling or fast precipitation from various solvent systems, all of which meet the particle size specification established to ensure equivalent biopharmaceutical performance. This work highlights the use of orthogonal surface techniques such as Inverse Gas Chromatography (IGC), Brunauer–Emmett–Teller (BET) surface area, contact angle, and X-ray Photoelectron Spectroscopy (XPS) to demonstrate the effect of processing history on particle surface properties to explain differences in bulk powder properties.

Funder

Merck & Co., Inc.

Publisher

MDPI AG

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