Chemodynamic Therapy of Glioblastoma Multiforme and Perspectives

Author:

Ullah Zia1,Abbas Yasir1,Gu Jingsi2,Ko Soe Sai1,Roy Shubham1ORCID,Peng Tingting3,Guo Bing1ORCID

Affiliation:

1. School of Science, Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen 518055, China

2. Education Center and Experiments and Innovations, Harbin Institute of Technology, Shenzhen 518055, China

3. State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Pharmacy, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou 511436, China

Abstract

Glioblastoma multiforme (GBM), a potential public health issue, is a huge challenge for the advanced scientific realm to solve. Chemodynamic therapy (CDT) based on the Fenton reaction emerged as a state-of-the-art therapeutic modality to treat GBM. However, crossing the blood–brain barrier (BBB) to reach the GBM is another endless marathon. In this review, the physiology of the BBB has been elaborated to understand the mechanism of crossing these potential barriers to treat GBM. Moreover, the designing of Fenton-based nanomaterials has been discussed for the production of reactive oxygen species in the tumor area to eradicate the cancer cells. For effective tumor targeting, biological nanomaterials that can cross the BBB via neurovascular transport channels have also been explored. To overcome the neurotoxicity caused by inorganic nanomaterials, the use of smart nanoagents having both enhanced biocompatibility and effective tumor targeting ability to enhance the efficiency of CDT are systematically summarized. Finally, the advancements in intelligent Fenton-based nanosystems for a multimodal therapeutic approach in addition to CDT are demonstrated. Hopefully, this systematic review will provide a better understanding of Fenton-based CDT and insight into GBM treatment.

Funder

Ministry of Education, China

National Natural Science Foundation of China

Guangdong Natural Science Foundation

Guangdong Basic and Applied Basic Research Foundation

Science and Technology Innovation Commission of Shenzhen

Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application

Publisher

MDPI AG

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