Near-Infrared Fluorescent Hydroxyapatite Nanoparticles for Targeted Photothermal Cancer Therapy

Author:

Jo Gayoung1,Park Yoonbin12,Park Min Ho3,Hyun Hoon12ORCID

Affiliation:

1. Department of Biomedical Sciences, Chonnam National University Medical School, Hwasun 58128, Republic of Korea

2. BioMedical Sciences Graduate Program (BMSGP), Chonnam National University, Hwasun 58128, Republic of Korea

3. Department of Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun 58128, Republic of Korea

Abstract

Near-infrared (NIR) fluorophores have attracted great attention due to their excellent optical and photothermal properties. Among them, a bone-targeted NIR fluorophore (named P800SO3) contains two phosphonate groups, which play important roles in binding with hydroxyapatite (HAP) as the main mineral component of bones. In this study, biocompatible and NIR fluorescent HAP nanoparticles functionalized with P800SO3 and polyethylene glycol (PEG) were readily prepared for tumor-targeted imaging and photothermal therapy (PTT). The PEGylated HAP nanoparticle (HAP800-PEG) demonstrated improved tumor targetability with high tumor-to-background ratios (TBR). Moreover, the HAP800-PEG also showed excellent photothermal properties, and the temperature of tumor tissue reached 52.3 °C under NIR laser irradiation, which could completely ablate the tumor tissue without recurrence. Therefore, this new type of HAP nanoparticle has great potential as a biocompatible and effective phototheranostic material, which enables the use of P800SO3 for targeted photothermal cancer treatment.

Funder

National Research Foundation of Korea

Chonnam National University Hwasun Hospital

Publisher

MDPI AG

Subject

Pharmaceutical Science

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