Abstract
Lesions can affect skin functions and cause a simple issue, such as dehydration, or more challenging complications, such as bacterial infections. The purpose of this study was to design composites for topical application that can prevent and/or assist in bacterial infections and support cell regeneration using natural components. A polyphenolic extract obtained from Salvia officinalis was embedded in functionalized mesoporous silica nanoparticles for better stability, followed by their distribution into a collagen porous scaffold. The resulting polyphenols-loaded MSN exhibited enhanced antibacterial activity and good cytocompatibility. Improved thermal stability of the collagen porous scaffold was obtained due to the presence of the functionalized MSN. For the first time, collagen-polyphenols-loaded silica composites were reported in the literature as potential wound dressings. The newly developed composites showed excellent sterility.
Funder
The Executive Agency for Financing of Higher Education, Research, Development, and Innovation (UEFISCDI) Romania
Reference53 articles.
1. Burn Injury: Challenges and Advances in Burn Wound Healing, Infection, Pain and Scarring;Wang;Adv. Drug Deliv. Rev.,2018
2. Burn Injury;Jeschke;Nat. Rev. Dis. Primers.,2020
3. World Health Organization (2022, December 08). Burns, Available online: https://www.who.int/news-room/fact-sheets/detail/burns.
4. Natural Composite Dressings Based on Collagen, Gelatin and Plant Bioactive Compounds for Wound Healing: A Review;Stanciuc;Int. J. Biol. Macromol.,2019
5. Recent Advances of Collagen-Based Biomaterials: Multi-Hierarchical Structure, Modification and Biomedical Applications;Liu;Mater. Sci. Eng. C,2019
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献