3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering

Author:

Tabriz Atabak Ghanizadeh12,Gonot-Munck Quentin3,Baudoux Arnaud3,Garg Vivek4ORCID,Farnish Richard4,Katsamenis Orestis L.5ORCID,Hui Ho-Wah6,Boersen Nathan6,Roberts Sandra6,Jones John7,Douroumis Dennis12ORCID

Affiliation:

1. Delta Pharmaceutics Ltd., Chatham, Kent ME4 4TB, UK

2. CRI Centre for Research Innovation, University of Greenwich, Chatham ME4 4TB, UK

3. Institute of Technology in Measurements and Instrumentation, University of Rouen, 76130 Mont Saint Aignan, France

4. The Wolfson Centre for Bulk Solids Handling Technology, Faculty of Engineering, Science University of Greenwich, Chatham ME4 4TB, UK

5. μ-VIS X-ray Imaging Centre, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton SO17 1BJ, UK

6. Drug Product Development, Bristol Myers Squibb, 556 Morris Avenue, Summit, NJ 07901, USA

7. Bristol Myers Squibb, Reeds Lane, Moreton, Wirral CH46 1QW, UK

Abstract

Selective laser sintering (SLS) has drawn attention for the fabrication of three-dimensional oral dosage forms due to the plurality of drug formulations that can be processed. The aim of this work was to employ SLS with a CO2 laser for the manufacturing of carvedilol personalised dosage forms of various strengths. Carvedilol (CVD) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64) blends of various ratios were sintered to produce CVD tablets of 3.125, 6.25, and 12.5 mg. The tuning of the SLS processing laser intensity parameter improved printability and impacted the tablet hardness, friability, CVD dissolution rate, and the total amount of drug released. Physicochemical characterization showed the presence of CVD in the amorphous state. X-ray micro-CT analysis demonstrated that the applied CO2 intensity affected the total tablet porosity, which was reduced with increased laser intensity. The study demonstrated that SLS is a suitable technology for the development of personalised medicines that meet the required specifications and patient needs.

Funder

National Research Facility for Lab-based X-ray CT

NVIDIA corporation

Publisher

MDPI AG

Subject

Pharmaceutical Science

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