Affiliation:
1. Department of Nuclear Medicine, Jeonbuk National University Medical School and Hospital, Jeonju 54907, Republic of Korea
2. Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea
Abstract
Hypoxia, a deficiency in the levels of oxygen, is a common feature of most solid tumors and induces many characteristics of cancer. Hypoxia is associated with metastases and strong resistance to radio- and chemotherapy, and can decrease the accuracy of cancer prognosis. Non-invasive imaging methods such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) using hypoxia-targeting radiopharmaceuticals have been used for the detection and therapy of tumor hypoxia. Nitroimidazoles are bioreducible moieties that can be selectively reduced under hypoxic conditions covalently bind to intracellular macromolecules, and are trapped within hypoxic cells and tissues. Recently, there has been a strong motivation to develop PET and SPECT radiotracers as radiopharmaceuticals containing nitroimidazole moieties for the visualization and treatment of hypoxic tumors. In this review, we summarize the development of some novel PET and SPECT radiotracers as radiopharmaceuticals containing nitroimidazoles, as well as their physicochemical properties, in vitro cellular uptake values, in vivo biodistribution, and PET/SPECT imaging results.
Funder
National Research Foundation of Korea
Reference193 articles.
1. Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects;Vaupel;JNCI J. Natl. Cancer Inst.,2001
2. Molecular imaging of hypoxia;Krohn;J. Nucl. Med.,2008
3. Oxygen and cancer;Dunn;N. C. Med. J.,1997
4. PET imaging of hypoxia;Lewis;Q. J. Nucl. Med. Mol. Imaging,2001
5. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix;Schienger;Cancer Res.,1996
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