Piezodynamic Eradication of Both Gram-Positive and Gram-Negative Bacteria by Using a Nanoparticle Embedded Polymeric Membrane
-
Published:2023-08-17
Issue:8
Volume:15
Page:2155
-
ISSN:1999-4923
-
Container-title:Pharmaceutics
-
language:en
-
Short-container-title:Pharmaceutics
Author:
Chen Chan1, Roy Shubham23ORCID, Wang Jingjing23, Lu Xiafen1, Li Siyi1, Yang Hao1, Cheng Minggang1, Guo Bing23ORCID, Xu Yuzhong1
Affiliation:
1. Department of Clinical Laboratory, Shenzhen Baoan Hospital, The Second Affiliated Hospital of Shenzhen University, Shenzhen 518000, China 2. School of Science, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen 518055, China 3. Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Harbin Institute of Technology, Shenzhen 518055, China
Abstract
Nowadays, bacterial infection is regarded as a serious threat to humankind, which needs to be taken care of. The emergence of antibiotic resistance and multidrug resistance (MDR) is rendering this situation more troublesome. However, several alternative treatment regimens have aided such diseases quite well in the recent past, among which dynamic antibacterial therapies combat this situation quite well. Among various dynamic therapies, piezodynamic therapy is a very recent avenue, in which mechanical stimuli have been exploited to treat bacterial infections. Herein, piezo-active bismuth ferrite-loaded poly(vinylidene fluoride-co-hexafluoropropylene) polymer has been utilized to eradicate gram-positive bacteria (E. faecalis) and gram-negative bacteria (E. coli). The sample has been designed in a free-standing membrane form, which, under soft ultrasound (~10 kHz), generates reactive radicals to ablate bacteria. Initially, the structure and morphology of the membrane have been substantiated by using X-ray diffraction and scanning electron microscopy methods; besides, Fourier transform infrared spectrum of the sample depicts a tremendously high value of polarizability and further confirms the piezo-activity of the membrane. More than 99% of E. coli and E. faecalis have been successfully eradicated within 30 min of ultrasound. Moreover, the solid-state structure and hydrophobic nature of the membrane help us to reuse it in a cyclic manner, which is possibly reported herein for the very first time. This novel membrane could be deployed in healthcare systems and pigment industries and could be exploited as a self-cleaning material.
Subject
Pharmaceutical Science
Reference41 articles.
1. Nanoparticle Mediated Stimuli Responsive Antibacterial Therapy;Bag;Biomater. Sci.,2023 2. A Review of Salmonella Enterica with Particular Focus on the Pathogenicity and Virulence Factors, Host Specificity and Antimicrobial Resistance Including Multidrug Resistance;Jajere;Vet. World,2019 3. Bacteriophage—A Promising Alternative Measure for Bacterial Biofilm Control;Tian;Infect. Drug Resist.,2021 4. Sieiro, C., Areal-hermida, L., Pichardo-gallardo, Á., Almuiña-gonzález, R., de Miguel, T., Sánchez, S., Sánchez-pérez, Á., and Villa, T.G. (2020). A Hundred Years of Bacteriophages: Can Phages Replace Antibiotics in Agriculture and Aquaculture?. Antibiotics, 9. 5. Bora, N.S., Mazumder, B., Pathak, M.P., Joshi, K., and Chattopadhyay, P. (2019). Nanotechnology, CRC Press.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|