Recent Progress in Extracellular Vesicle-Based Carriers for Targeted Drug Delivery in Cancer Therapy

Author:

Tang Yaqin12,Liu Xingyou1,Sun Meng1,Xiong Su1,Xiao Nianting1,Li Jianchao1,He Xiao1,Xie Jing1

Affiliation:

1. Chongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, China

2. College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China

Abstract

Extracellular vesicles (EVs) are small, membrane-based vesicles released by cells that play a critical role in various physiological and pathological processes. They act as vehicles for transporting a variety of endogenous cargo molecules, enabling intercellular communication. Due to their natural properties, EVs have emerged as a promising “cell-free therapy” strategy for treating various diseases, including cancer. They serve as excellent carriers for different therapeutics, including nucleic acids, proteins, small molecules, and other nanomaterials. Modifying or engineering EVs can improve the efficacy, targeting, specificity, and biocompatibility of EV-based therapeutics for cancer therapy. In this review, we comprehensively outline the biogenesis, isolation, and methodologies of EVs, as well as their biological functions. We then focus on specific applications of EVs as drug carriers in cancer therapy by citing prominent recent studies. Additionally, we discuss the opportunities and challenges for using EVs as pharmaceutical drug delivery vehicles. Ultimately, we aim to provide theoretical and technical support for the development of EV-based carriers for cancer treatment.

Funder

Science and Technology Research Program of the Chongqing Education Commission of China

Scientific Research Foundation of Chongqing University of Technology

Natural Science Foundation Project of CQCSTC

Science and Technology Research Program of Chongqing Municipal Education Commission

Science and Technology Talents in Banan District of Chongqing

Graduate Scientific Research and Innovation Foundation of Chongqing, China

Publisher

MDPI AG

Subject

Pharmaceutical Science

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