A Review of the Benefits 3D Printing Brings to Patients with Neurological Diseases

Author:

Gander Christine1ORCID,Shi Kejing2ORCID,Nokhodchi Ali13,Lam Matthew14

Affiliation:

1. Pharmaceutics Research Laboratory, Arundel Building, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK

2. Medicines Research Group, School of Health, Sport and Bioscience, University of East London, Water Lane, London E15 4LZ, UK

3. Lupin Pharmaceutical Research Center, 4006 NW 124th Ave., Coral Springs, FL 33065, USA

4. Department of Chemical and Pharmaceutical Sciences, School of Human Sciences, London Metropolitan University, 166-220 Holloway Road, London N7 8DB, UK

Abstract

This interdisciplinary review focuses on how flexible three-dimensional printing (3DP) technology can aid patients with neurological diseases. It covers a wide variety of current and possible applications ranging from neurosurgery to customizable polypill along with a brief description of the various 3DP techniques. The article goes into detail about how 3DP technology can aid delicate neurosurgical planning and its consequent outcome for patients. It also covers areas such as how the 3DP model can be utilized in patient counseling along with designing specific implants involved in cranioplasty and customization of a specialized instrument such as 3DP optogenetic probes. Furthermore, the review includes how a 3DP nasal cast can contribute to the development of nose-to-brain drug delivery along with looking into how bioprinting could be used for regenerating nerves and how 3D-printed drugs could offer practical benefits to patients suffering from neurological diseases via polypill.

Publisher

MDPI AG

Subject

Pharmaceutical Science

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