Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications
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Published:2023-04-21
Issue:4
Volume:15
Page:1313
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ISSN:1999-4923
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Container-title:Pharmaceutics
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language:en
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Short-container-title:Pharmaceutics
Author:
Desai Nimeet1ORCID, Rana Dhwani2, Salave Sagar2ORCID, Gupta Raghav2, Patel Pranav2, Karunakaran Bharathi2, Sharma Amit2, Giri Jyotsnendu1, Benival Derajram2, Kommineni Nagavendra3ORCID
Affiliation:
1. Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502285, India 2. National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, India 3. Center for Biomedical Research, Population Council, New York, NY 10065, USA
Abstract
Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as a material of promise for drug delivery and biomedical applications. Different chitin and chitosan extraction techniques can produce materials with unique properties, which can be further modified to enhance their bioactivities. Chitosan-based drug delivery systems have been developed for various routes of administration, including oral, ophthalmic, transdermal, nasal, and vaginal, allowing for targeted and sustained release of drugs. Additionally, chitosan has been used in numerous biomedical applications, such as bone regeneration, cartilage tissue regeneration, cardiac tissue regeneration, corneal regeneration, periodontal tissue regeneration, and wound healing. Moreover, chitosan has also been utilized in gene delivery, bioimaging, vaccination, and cosmeceutical applications. Modified chitosan derivatives have been developed to improve their biocompatibility and enhance their properties, resulting in innovative materials with promising potentials in various biomedical applications. This article summarizes the recent findings on chitosan and its application in drug delivery and biomedical science.
Subject
Pharmaceutical Science
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