Electrospun Fibrous Silica for Bone Tissue Engineering Applications

Author:

Stoica (Oprea) Alexandra Elena1,Bîrcă Alexandra Cătălina1,Gherasim Oana2,Ficai Anton1ORCID,Grumezescu Alexandru Mihai134ORCID,Oprea Ovidiu-Cristian45ORCID,Vasile Bogdan Ștefan678ORCID,Balta Cornel9ORCID,Andronescu Ecaterina14ORCID,Hermenean Anca Oana9

Affiliation:

1. Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania

2. Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Romania

3. Research Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, Romania

4. Academy of Romanian Scientists, Ilfov No. 3, 050044 Bucharest, Romania

5. Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania

6. National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania

7. HTP Research and Consulting, Joita, 087150 Giurgiu, Romania

8. Research Center for Advanced Materials, Products and Processes, University of Bucharest, 060042 Bucharest, Romania

9. “Aurel Ardelean” Institute of Life Sciences, Vasile Goldiş Western University of Arad, 310025 Arad, Romania

Abstract

The production of highly porous and three-dimensional (3D) scaffolds with biomimicking abilities has gained extensive attention in recent years for tissue engineering (TE) applications. Considering the attractive and versatile biomedical functionality of silica (SiO2) nanomaterials, we propose herein the development and validation of SiO2-based 3D scaffolds for TE. This is the first report on the development of fibrous silica architectures, using tetraethyl orthosilicate (TEOS) and polyvinyl alcohol (PVA) during the self-assembly electrospinning (ES) processing (a layer of flat fibers must first be created in self-assembly electrospinning before fiber stacks can develop on the fiber mat). The compositional and microstructural characteristics of obtained fibrous materials were evaluated by complementary techniques, in both the pre-ES aging period and post-ES calcination. Then, in vivo evaluation confirmed their possible use as bioactive scaffolds in bone TE.

Funder

European Social Fund within the Sectorial Operational Program Human Capital

Romanian Governmental through the National Programme “Installations and Strategic Objectives of National Interest”

Publisher

MDPI AG

Subject

Pharmaceutical Science

Reference99 articles.

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