Gold Nanoparticles: Construction for Drug Delivery and Application in Cancer Immunotherapy

Author:

Huang Huiqun12,Liu Ronghui3,Yang Jie2,Dai Jing2,Fan Shuhao4,Pi Jiang4ORCID,Wei Yubo5,Guo Xinrong12ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, China

2. Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China

3. School of Microelectronic, Southern University of Science and Technology, Shenzhen 518000, China

4. Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan 523808, China

5. Yunnan Key Laboratory of Pharmacology for Natural Products, School of Pharmaceutical Sciences, Kunming Medical University, Kunming 650500, China

Abstract

Cancer immunotherapy is an innovative treatment strategy to enhance the ability of the immune system to recognize and eliminate cancer cells. However, dose limitations, low response rates, and adverse immune events pose significant challenges. To address these limitations, gold nanoparticles (AuNPs) have been explored as immunotherapeutic drug carriers owing to their stability, surface versatility, and excellent optical properties. This review provides an overview of the advanced synthesis routes for AuNPs and their utilization as drug carriers to improve precision therapies. The review also emphasises various aspects of AuNP-based immunotherapy, including drug loading, targeting strategies, and drug release mechanisms. The application of AuNPs combined with cancer immunotherapy and their therapeutic efficacy are briefly discussed. Overall, we aimed to provide a recent understanding of the advances, challenges, and prospects of AuNPs for anticancer applications.

Funder

National Natural Science Foundation of China

Guangdong Basic and Applied Basic Research Foundation

Guangdong Medical University

Yunnan Fundamental Research Projects

Applied Basic Research Joint Special Project of Kunming Medical University

Yunnan Province’s “Xingdian Talent Support Project

Publisher

MDPI AG

Subject

Pharmaceutical Science

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