The Effects of Ellagic Acid on Experimental Corrosive Esophageal Burn Injury

Author:

Keşim Dilek Aygün1ORCID,Aşır Fırat2,Ayaz Hayat2,Korak Tuğcan3

Affiliation:

1. Department of Physiology, Medical Faculty, Dicle University, Diyarbakır 21280, Turkey

2. Department of Histology and Embryology, Medical Faculty, Dicle University, Diyarbakır 21280, Turkey

3. Department of Medical Biology, Medical Faculty, Kocaeli University, Kocaeli 41001, Turkey

Abstract

This study aimed to investigate the antioxidant effect of Ellagic acid (EA) on wound healing in sodium hydroxide (NaOH)-induced corrosive esophageal burn injury. The interaction networks and functional annotations were conducted using Cytoscape software. A total of 24 Wistar albino rats were divided into control, corrosive esophageal burn (CEB) and CEB + EA groups. Burn injury was created by 20% NaOH and 30 mg/kg EA was per oral administered to rats. At the end of the 28-day experimental period, Malondialdehyde (MDA) content was measured. Esophageal tissue samples were processed for histological staining. The EA–target interaction network was revealed to be involved in regulating crucial cellular mechanisms for burn wound healing, with epidermal growth factor (EGF) identified as a central mediator. An increase in animal weight in the CEB + EA group was observed in the EA-treated group after CEB injury. Burn injury increased MDA content, but EA treatment decreased its level after CEB injury. Stenosis index, collagen degeneration, inflammation, fibrosis and necrosis levels were increased after CEB injury. EA treatment improved histopathology in the CEB + EA group compared to the CEB group. The expression of EGF was decreased in the CEB group but upregulated in the EA-treated group, suggesting a potential involvement of EA in cellular processes and tissue regeneration. EA, through its antioxidative and tissue regenerative properties, significantly contributes to alleviating the adverse effects of CEB injury, promoting wound healing.

Publisher

MDPI AG

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